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We reviewed 3 live results for oligo immobilization and narrowed them down to the 3 options that look most worth comparing first.
The options are Small Nucleic Acid Drug Conjugation Service, BcMag™ Quick Oligo-DNA Conjugation Kit and Antibody-Oligonucleotide Conjugation Service.
Source: GenScript
Description
GenScript provides small nucleic acid drug conjugation services, linking siRNA or ASO payloads with antibodies, proteins, or peptides to facilitate targeted delivery and gene silencing. The end-to-end platform supports antibody-oligo conjugates (AOCs), peptide-oligo conjugates (POCs), and antibody-peptide conjugates (APCs) using random or site-specific methods, customizable linkers, and varied drug-to-antibody ratio (DAR) values. Offerings include synthesis, multi-orthogonal QC characterization, in vitro and in vivo verification, and non-GMP manufacturing.
Best for
Biopharmaceutical researchers, Drug discovery scientists, Developing targeted siRNA and ASO therapeutics and Creating antibody-oligo or peptide-oligo conjugates
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Source: Bioclone
Description
The BcMag™ Quick Oligo-DNA Conjugation Kit by Bioclone is designed to quickly and efficiently immobilize amine-modified oligonucleotide DNA onto carboxyl-activated superparamagnetic beads using the EDC cross-linker. Featuring a one-step protocol that forms stable neutral amide bonds with minimal ligand leakage and high immobilization efficiency, the kit yields conjugates suitable for downstream molecular biology applications including PCR, hybridization, DNA/RNA sequencing, mutation detection, and genotyping. Available in 100 mg and 200 mg bead kit formats.
Best for
Molecular biology researchers and Immobilizing amine-modified oligo-DNA onto magnetic beads for PCR, sequencing, and hybridization assays
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Source: AlphaThera
Description
AlphaThera provides custom Antibody-Oligonucleotide Conjugation Services utilizing proprietary oYo-Link site-specific labeling technology. The service delivers covalent antibody-oligo conjugates with over 90% conjugation efficiency, limiting excess unlabeled material and maintaining consistent degree of labeling across multiple antibody subclasses. Priced starting at $75 per conjugate plus reagents, the workflow supports antibody concentrations as dilute as 50 µg/mL without preset quantity limits. Customers supply oligo sequences sourced via IDT and ship antibodies to AlphaThera's Philadelphia facility. Optional FPLC or magnetic bead purification and SDS-PAGE quality control validation are also provided.
Best for
researchers, conjugation scientists, antibody-oligonucleotide conjugation and highly sensitive assays
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| Compare | #1Small Nucleic Acid Drug Conjugation Service | #2BcMag™ Quick Oligo-DNA Conjugation Kit | #3Antibody-Oligonucleotide Conjugation Service |
|---|---|---|---|
| Source | GenScript | Bioclone | AlphaThera |
| Description | GenScript provides small nucleic acid drug conjugation services, linking siRNA or ASO payloads with antibodies, proteins, or peptides to facilitate targeted delivery and gene silencing. The end-to-end platform supports antibody-oligo conjugates (AOCs), peptide-oligo conjugates (POCs), and antibody-peptide conjugates (APCs) using random or site-specific methods, customizable linkers, and varied drug-to-antibody ratio (DAR) values. Offerings include synthesis, multi-orthogonal QC characterization, in vitro and in vivo verification, and non-GMP manufacturing. | The BcMag™ Quick Oligo-DNA Conjugation Kit by Bioclone is designed to quickly and efficiently immobilize amine-modified oligonucleotide DNA onto carboxyl-activated superparamagnetic beads using the EDC cross-linker. Featuring a one-step protocol that forms stable neutral amide bonds with minimal ligand leakage and high immobilization efficiency, the kit yields conjugates suitable for downstream molecular biology applications including PCR, hybridization, DNA/RNA sequencing, mutation detection, and genotyping. Available in 100 mg and 200 mg bead kit formats. | AlphaThera provides custom Antibody-Oligonucleotide Conjugation Services utilizing proprietary oYo-Link site-specific labeling technology. The service delivers covalent antibody-oligo conjugates with over 90% conjugation efficiency, limiting excess unlabeled material and maintaining consistent degree of labeling across multiple antibody subclasses. Priced starting at $75 per conjugate plus reagents, the workflow supports antibody concentrations as dilute as 50 µg/mL without preset quantity limits. Customers supply oligo sequences sourced via IDT and ship antibodies to AlphaThera's Philadelphia facility. Optional FPLC or magnetic bead purification and SDS-PAGE quality control validation are also provided. |
| Best for | Biopharmaceutical researchers, Drug discovery scientists, Developing targeted siRNA and ASO therapeutics and Creating antibody-oligo or peptide-oligo conjugates | Molecular biology researchers and Immobilizing amine-modified oligo-DNA onto magnetic beads for PCR, sequencing, and hybridization assays | researchers, conjugation scientists, antibody-oligonucleotide conjugation and highly sensitive assays |
| Action | GenScript | Bioclone | AlphaThera |
| Rate this product |
"Small Nucleic Acid Drug Conjugation Service from GenScript."
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